USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: GPX1_HUMAN USC-OGP 2-DE database:  GPX1_HUMAN GPX1_HUMAN General information about the entry View entry in simple text format Entry name GPX1_HUMAN Primary accession number P07203 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Glutathione peroxidase 1; Short=GPx-1; Short=GSHPx-1; EC=1.11.1.9; AltName: Full=Cellular glutathione peroxidase;. Gene name Name=GPX1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0556: pI=5.86; Mw=21730 SPOT OGP-0558: pI=5.54; Mw=21597 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0841: pI=5.56; Mw=18748 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1300: pI=5.70; Mw=23333 Cross-references UniProtKB/Swiss-Prot P07203; GPX1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name GPX1_HUMAN Primary accession number P07203 Secondary accession number(s) E9PAS1 Q7Z5H1 Q9BW12 Sequence was last modified on  November 2, 2010 (version 4) Annotations were last modified on  March 15, 2017 (version 197) Name and origin of the protein Description RecName: Full=Glutathione peroxidase 1; Short=GPx-1; Short=GSHPx-1; EC=1.11.1.9; AltName: Full=Cellular glutathione peroxidase; Gene name Name=GPX1 Encoded on Name=GPX1 Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Oxidoreductase; Peroxidase; Phosphoprotein; Polymorphism; Reference proteome; Selenocysteine. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL Y00433; CAA68491.1; -; mRNA EMBL Y00483; CAB37833.1; -; Genomic_DNA EMBL X13709; CAA31992.1; -; mRNA EMBL X13710; CAA31993.1; -; mRNA EMBL M21304; AAA75389.2; -; mRNA EMBL M83094; AAA67540.2; -; Genomic_DNA EMBL AY327818; AAP80181.1; -; Genomic_DNA EMBL AC121247; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC000742; AAH00742.3; -; mRNA CCDS CCDS43091.1; -. [P07203-1]; . CCDS CCDS54582.1; -. [P07203-2]; . PIR A42152; OPHUE; . RefSeq NP_000572.2; NM_000581.3. [P07203-1]; . UniGene Hs.76686; -; . PDB 2F8A; X-ray; 1.50 A; A/B=14-198 PDBsum 2F8A; -; . ProteinModelPortal P07203; -; . SMR P07203; -; . BioGrid 109134; 15; . IntAct P07203; 10; . STRING 9606.ENSP00000407375; -; . BindingDB P07203; -; . ChEMBL CHEMBL2163186; -; . DrugBank DB00143; Glutathione; . SwissLipids SLP:000001632; -; . PeroxiBase 3600; HsGPx01-A; . iPTMnet P07203; -; . PhosphoSitePlus P07203; -; . SwissPalm P07203; -; . BioMuta GPX1; -; . DMDM 311033481; -; . OGP P07203; -; . SWISS-2DPAGE P07203; -; . EPD P07203; -; . PaxDb P07203; -; . PeptideAtlas P07203; -; . PRIDE P07203; -; . DNASU 2876; -; . Ensembl ENST00000419349; ENSP00000391316; ENSG00000233276. [P07203-2]; . Ensembl ENST00000419783; ENSP00000407375; ENSG00000233276. [P07203-1]; . GeneID 2876; -; . KEGG hsa:2876; -; . UCSC uc021wxw.2; human. [P07203-1]; . CTD 2876; -; . DisGeNET 2876; -; . GeneCards GPX1; -; . H-InvDB HIX0003298; -; . HGNC HGNC:4553; GPX1; . HPA CAB011582; -; . HPA HPA044758; -; . MalaCards GPX1; -; . MIM 138320; gene+phenotype; . neXtProt NX_P07203; -; . OpenTargets ENSG00000233276; -; . PharmGKB PA28949; -; . eggNOG KOG1651; Eukaryota; . eggNOG COG0386; LUCA; . GeneTree ENSGT00760000119230; -; . HOGENOM HOG000277055; -; . HOVERGEN HBG004333; -; . InParanoid P07203; -; . KO K00432; -; . OMA CEVNGEK; -; . OrthoDB EOG091G10LN; -; . PhylomeDB P07203; -; . TreeFam TF105318; -; . BioCyc MetaCyc:HS00019-MONOMER; -; . BRENDA 1.11.1.9; 2681; . Reactome R-HSA-2142688; Synthesis of 5-eicosatetraenoic acids; . Reactome R-HSA-2142712; Synthesis of 12-eicosatetraenoic acid derivatives; . Reactome R-HSA-2142770; Synthesis of 15-eicosatetraenoic acid derivatives; . Reactome R-HSA-3299685; Detoxification of Reactive Oxygen Species; . Reactome R-HSA-74259; Purine catabolism; . SIGNOR P07203; -; . ChiTaRS GPX1; human; . EvolutionaryTrace P07203; -; . GeneWiki GPX1; -; . GenomeRNAi 2876; -; . PRO PR:P07203; -; . Proteomes UP000005640; Chromosome 3; . Bgee ENSG00000233276; -; . CleanEx HS_GPX1; -; . ExpressionAtlas P07203; baseline and differential; . Genevisible P07203; HS; . GO GO:0005737; C:cytoplasm; IDA:BHF-UCL; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005759; C:mitochondrial matrix; TAS:Reactome; . GO GO:0005739; C:mitochondrion; IDA:BHF-UCL; . GO GO:0004602; F:glutathione peroxidase activity; IDA:BHF-UCL; . GO GO:0017124; F:SH3 domain binding; IPI:BHF-UCL; . GO GO:0060055; P:angiogenesis involved in wound healing; IEA:Ensembl; . GO GO:0043534; P:blood vessel endothelial cell migration; IEA:Ensembl; . GO GO:0045454; P:cell redox homeostasis; IDA:BHF-UCL; . GO GO:0034599; P:cellular response to oxidative stress; NAS:ParkinsonsUK-UCL; . GO GO:0001885; P:endothelial cell development; IEA:Ensembl; . GO GO:0045444; P:fat cell differentiation; IEA:Ensembl; . GO GO:0006749; P:glutathione metabolic process; IDA:BHF-UCL; . GO GO:0060047; P:heart contraction; IMP:BHF-UCL; . GO GO:0042744; P:hydrogen peroxide catabolic process; IDA:BHF-UCL; . GO GO:0051702; P:interaction with symbiont; IEA:Ensembl; . GO GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IEA:Ensembl; . GO GO:0019372; P:lipoxygenase pathway; TAS:Reactome; . GO GO:0051450; P:myoblast proliferation; IEA:Ensembl; . GO GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:BHF-UCL; . GO GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IMP:BHF-UCL; . GO GO:0002862; P:negative regulation of inflammatory response to antigenic stimulus; IEA:Ensembl; . GO GO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl; . GO GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IMP:BHF-UCL; . GO GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl; . GO GO:1902905; P:positive regulation of supramolecular fiber organization; ISS:ParkinsonsUK-UCL; . GO GO:0018158; P:protein oxidation; IEA:Ensembl; . GO GO:0006195; P:purine nucleotide catabolic process; TAS:Reactome; . GO GO:0040029; P:regulation of gene expression; epigenetic; IDA:BHF-UCL GO GO:0033599; P:regulation of mammary gland epithelial cell proliferation; IMP:BHF-UCL; . GO GO:0043523; P:regulation of neuron apoptotic process; IEA:Ensembl; . GO GO:0061136; P:regulation of proteasomal protein catabolic process; IDA:BHF-UCL; . GO GO:0010332; P:response to gamma radiation; IEA:Ensembl; . GO GO:0042542; P:response to hydrogen peroxide; IMP:BHF-UCL; . GO GO:0033194; P:response to hydroperoxide; IEA:Ensembl; . GO GO:0000302; P:response to reactive oxygen species; TAS:Reactome; . GO GO:0010269; P:response to selenium ion; IMP:BHF-UCL; . GO GO:0009609; P:response to symbiotic bacterium; IEA:Ensembl; . GO GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl; . GO GO:0007605; P:sensory perception of sound; IEA:Ensembl; . GO GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl; . GO GO:0043403; P:skeletal muscle tissue regeneration; IEA:Ensembl; . GO GO:0001659; P:temperature homeostasis; IEA:Ensembl; . GO GO:0006641; P:triglyceride metabolic process; IEA:Ensembl; . GO GO:0009650; P:UV protection; IMP:BHF-UCL; . GO GO:0042311; P:vasodilation; IEA:Ensembl; . CDD cd00340; GSH_Peroxidase; 1; . Gene3D 3.40.30.10; -; 1; . InterPro IPR000889; Glutathione_peroxidase; . InterPro IPR029759; GPX_AS; . InterPro IPR029760; GPX_CS; . InterPro IPR012336; Thioredoxin-like_fold; . PANTHER PTHR11592; PTHR11592; 1; . Pfam PF00255; GSHPx; 1; . PIRSF PIRSF000303; Glutathion_perox; 1; . PRINTS PR01011; GLUTPROXDASE; . SUPFAM SSF52833; SSF52833; 1; . PROSITE PS00460; GLUTATHIONE_PEROXID_1; 1; . PROSITE PS00763; GLUTATHIONE_PEROXID_2; 1; . PROSITE PS51355; GLUTATHIONE_PEROXID_3; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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